Later prehistory from the Trent to the Tyne

The object of the thesis is to present a study of the later Bronze Age and Iron Age periods in the area from the river Tyne southwards to the English Midlands. A large quantity of unpublished material is illustrated, and is discussed in a suggested chronological sequence devised on the basis of site association and relevant British and European context. The evidence of settlement sites, economy, and burial is also reviewed. Specific conclusions have been reached throughout all aspects of the discussion. To a great extent these conclusions are provisional, since much evidence is not yet published and research in many fields has been limited, but some are of considerable importance. Pottery forms owing much to earlier urn styles are identified in the Late Bronze Age alongside intrusive types. The widespread influence of Hallstatt traits is discussed. The scored pottery of the East Midlands is seen to have been introduced in the fifth century B.C. or even earlier. The identification of distinctive "angular" pottery in the East Riding adds credence to the theory of an early La Tene immigration. The importance of arable farming in the Iron Age food-producing economy, and the development of an enclosed, intensively occupied landscape in parts of the south and east are shown. The fact that most excavated hill-forts in the area are demonstrably pre-fifth century B.C. is highlighted. An analysis of the distinctive character of constituent parts of the area of study is made. The results of palynological investigations are cited whenever possible to demonstrate the presence, character, and effects of prehistoric populations. It is seen that the paucity of material evidence from the north and west is not wholly a result of an imbalance in research effort. Suggestions for future work are made

Gut-seeded α-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice

Parkinson’s disease is a synucleinopathy that is characterized by motor dysfunction, death of midbrain dopaminergic neurons and accumulation of α-synuclein (α-Syn) aggregates. Evidence suggests that α-Syn aggregation can originate in peripheral tissues and progress to the brain via autonomic fibers. We tested this by inoculating the duodenal wall of mice with α-Syn preformed fibrils. Following inoculation, we observed gastrointestinal deficits and physiological changes to the enteric nervous system. Using the AAV-PHP.S capsid to target the lysosomal enzyme glucocerebrosidase for peripheral gene transfer, we found that α-Syn pathology is reduced due to the increased expression of this protein. Lastly, inoculation of α-Syn fibrils in aged mice, but not younger mice, resulted in progression of α-Syn histopathology to the midbrain and subsequent motor defects. Our results characterize peripheral synucleinopathy in prodromal Parkinson’s disease and explore cellular mechanisms for the gut-to-brain progression of α-Syn pathology

Developing the evidence base for adult social care practice: The NIHR School for Social Care Research

In a foreword to 'Shaping the Future of Care Together', Prime Minister Gordon Brown says that a care and support system reflecting the needs of our times and meeting our rising aspirations is achievable, but 'only if we are prepared to rise to the challenge of radical reform'. A number of initiatives will be needed to meet the challenge of improving social care for the growing older population. Before the unveiling of the green paper, The National Institute for Health Research (NIHR) announced that it has provided 15m pounds over a five-year period to establish the NIHR School for Social Care Research. The School's primary aim is to conduct or commission research that will help to improve adult social care practice in England. The School is seeking ideas for research topics, outline proposals for new studies and expert advice in developing research methods

Client self-assessment in community aged care: A comparative study involving older Australians and their case managers

Self-assessment of support needs is a relatively new and under-researched phenomenon in domiciliary aged care. This article outlines the results of a comparative study focusing on whether a self-assessment approach assists clients to identify support needs and the degree to which self-assessed needs differ from an assessment conducted by community care professionals. A total of 48 older people and their case managers completed a needs assessment tool. Twenty-two semi-structured interviews were used to ascertain older people’s views and preferences regarding the self-assessment process. The study suggests that while a co-assessment approach as outlined in this article has the potential to assist older people to gain a better understanding of their care needs as well as the assessment process and its ramifications, client self-assessment should be seen as part of a co-assessment process involving care professionals. Such a co-assessment process allows older people to gain a better understanding of their support needs and the wider community aged care context. The article suggests that a co-assessment process involving both clients and care professionals contains features that have the capacity to enhance domiciliary aged care

Nonlinear atom-optical delta-kicked harmonic oscillator using a Bose-Einstein condensate

We experimentally investigate the atom-optical delta-kicked harmonic oscillator for the case of nonlinearity due to collisional interactions present in a Bose-Einstein condensate. A Bose condensate of rubidium atoms tightly confined in a static harmonic magnetic trap is exposed to a one-dimensional optical standing-wave potential that is pulsed on periodically. We focus on the quantum anti-resonance case for which the classical periodic behavior is simple and well understood. We show that after a small number of kicks the dynamics is dominated by dephasing of matter wave interference due to the finite width of the condensate's initial momentum distribution. In addition, we demonstrate that the nonlinear mean-field interaction in a typical harmonically confined Bose condensate is not sufficient to give rise to chaotic behavior.Comment: 4 pages, 3 figure

SN~1991T: Reflections of Past Glory

We have obtained photometry and spectra of SN~1991T which extend more than 1000 days past maximum light, by far the longest a SN~Ia has been followed. Although SN~1991T exhibited nearly normal photometric behavior in the first 400 days following maximum, by 600 days its decline had slowed, and by 950~days the supernova brightness was consistent with a constant apparent magnitude of $m_B=21.30$. Spectra near maximum showed minor variations on the SN~Ia theme which grew less conspicuous during the exponential decline. At 270 days the nebular spectrum was composed of Fe and Co lines common to SNe~Ia. However, by 750 days past maximum light, these lines had shifted in wavelength, and were superimposed on a strong blue continuum. The luminosity of SN~1991T at 950 days is more than $9.0\times10^{38}(D/13~{\rm Mpc})^2$~ergs~s$^{-1}$ with a rate of decline of less than $0.04$ mags/100~days. We show that this emission is likely to be light that was emitted by SN~1991T near maximum light which has reflected from foreground dust, much like the light echos observed around SN~1987A.Comment: 15 pages (includes figures and tables) uuencoded compressed postscript, CfA Preprint - To Appear in ApJ